联合治疗对宫颈癌女性血清中组织蛋白酶D和α-1-抗胰蛋白酶活性的影响。
The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer.
作者信息
Woźniak B, Mila-Kierzenkowska C, Woźniak A, Drewa G, Sopońska M, Drewa T, Krzyzyńska-Malinowska E, Makarewicz R, Kowalski T, Szmytkowska K
机构信息
Department and Clinic of Neurosurgery and Neurotraumatology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
出版信息
Eur J Gynaecol Oncol. 2008;29(6):617-9.
PURPOSE OF INVESTIGATION
The aim of the study was to determine the activity of cathepsin D (CTSD) and alpha-1-antitrypsin (AAT) in the blood serum of women with cervical carcinoma treated with different modes of therapy.
METHODS
The study was conducted on 68 women suffering from carcinoma of the uterine cervix, that were irradiated intracavitarily by a Selectron LDR brachytherapy unit. Additionally, all patients were treated with different therapy methods according to clinical stage.
RESULTS
In women with cervical cancer, CTSD activity was higher while AAT activity was lower both before and after brachytherapy sessions as compared to controls. Six months after the end of therapy, the activity of CTSD and AAT reverted back to the values characteristic for healthy women.
CONCLUSION
The estimation of cathepsin D and alpha-1-antitrypsin activity during the course of cervical cancer management may be useful in early detection of potential recurrence and/or widespread metastasis formation.
研究目的
本研究的目的是确定采用不同治疗方式治疗的宫颈癌女性血清中组织蛋白酶D（CTSD）和α-1抗胰蛋白酶（AAT）的活性。
方法
对68例子宫颈癌女性进行了研究，这些患者通过Selectron LDR近距离治疗装置进行腔内照射。此外，所有患者根据临床分期采用不同的治疗方法。
结果
与对照组相比，宫颈癌女性在近距离治疗前后CTSD活性较高而AAT活性较低。治疗结束6个月后，CTSD和AAT的活性恢复到健康女性的特征值。
结论
在宫颈癌治疗过程中评估组织蛋白酶D和α-1抗胰蛋白酶的活性可能有助于早期发现潜在的复发和/或广泛转移的形成。
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