胆碱能系统在物体位置联想识别记忆中的关键作用。
Critical role of the cholinergic system for object-in-place associative recognition memory.
作者信息
Barker Gareth R I, Warburton Elizabeth C
机构信息
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom.
出版信息
Learn Mem. 2008 Dec 30;16(1):8-11. doi: 10.1101/lm.1121309. Print 2009 Jan.
Abstract
Object-in-place memory, which relies on the formation of associations between an object and the place in which it was encountered, depends upon a neural circuit comprising the perirhinal (PRH) and medial prefrontal (mPFC) cortices. This study examined the contribution of muscarinic cholinergic neurotransmission within this circuit to such object-in-place associative memory. Intracerebral administration of scopolamine in the PRH or mPFC impaired memory acquisition, but not retrieval and importantly we showed that unilateral blockade of muscarinic receptors simultaneously in both regions in opposite hemispheres, significantly impaired performance. Thus, object-in-place associative memory depends upon cholinergic modulation of neurones within the PRH-PFC circuit.
摘要
物体定位记忆依赖于物体与其被遇到的位置之间关联的形成，它取决于一个由嗅周皮质（PRH）和内侧前额叶皮质（mPFC）组成的神经回路。本研究考察了该回路中M胆碱能神经传递对这种物体定位联想记忆的作用。在PRH或mPFC内脑内注射东莨菪碱会损害记忆获取，但不影响记忆提取，并且重要的是，我们发现同时在相对半球的两个区域单侧阻断M受体，会显著损害记忆表现。因此，物体定位联想记忆依赖于PRH-PFC回路中神经元的胆碱能调节。
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