体外培养的艾氏腹水癌细胞中次黄嘌呤代谢的抑制剂
Inhibitors of hypoxanthine metabolism in Ehrlich ascites tumor cells in vitro.
作者信息
Smith C M, Zombor G, Henderson J F
出版信息
Cancer Treat Rep. 1976 Oct;60(10):1567-84.
PMID:191189
Abstract
One hundred and sixty-one purine analogs and derivatives were tested for their ability to inhibit ten parameters of purine metabolism in Ehrlich ascites tumor cells incubated in vitro with radioactive hypoxanthine. Sixty-seven compounds were inhibitory against at least one parameter and 30 were inhibitory against two or more.
摘要
对161种嘌呤类似物和衍生物进行了测试，以检测它们在体外与放射性次黄嘌呤一起孵育的艾氏腹水瘤细胞中抑制嘌呤代谢十个参数的能力。67种化合物对至少一个参数有抑制作用，30种对两个或更多参数有抑制作用。
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