Aghakhani Nozar, Durand Philippe, Chevret Laurent, Parker Fabrice, Devictor Denis, Tardieu Marc, Tadié Marc
Department of Neurosurgery, Bicêtre University Hospital, Bicêtre, France. nozar.
J Neurosurg Pediatr. 2009 Jan;3(1):66-9. doi: 10.3171/2008.10.PEDS08116.
In this study, the authors investigated the clinical efficacy of decompressive craniectomy treatments for nontraumatic intracranial hypertension in children.
Seven patients with nontraumatic refractory high intracranial pressure (ICP) were enrolled in the study between 1995 and 2005; there were 2 boys and 5 girls with a mean age of 9 years (range 4-14). Decompressive craniectomy was performed in all patients after standard medical therapy had proven insufficient and ICP remained > 50 mm Hg. All patients had a Glasgow Coma Scale score < 8 at admission and a mean Pediatric Risk of Mortality Scale score of 20 (range 10-27).
One patient died of persistent high ICP and circulatory failure 48 hours after surgery. Six months later, according to their Glasgow Outcome Scale scores, 3 patients had adequate recoveries, 2 patients recovered with moderate disabilities, and 1 patient had severe disabilities. According to the Pediatric Overall Performance Category Scale, 4 patients received a score of 2 (mild disability), 1 a score of 3 (moderate disability), and 1 a score of 4 (severe disability). Five patients returned to school and normal life.
The authors found decompressive craniectomy to be an effective and lifesaving technique in children. This procedure should be included in the arsenal of treatments for nontraumatic intracranial hypertension.
在本研究中,作者调查了减压颅骨切除术治疗儿童非创伤性颅内高压的临床疗效。
1995年至2005年间,7例非创伤性难治性高颅内压(ICP)患者纳入本研究;其中2例男孩,5例女孩,平均年龄9岁(范围4 - 14岁)。在标准药物治疗被证明无效且ICP仍>50 mmHg后,所有患者均接受了减压颅骨切除术。所有患者入院时格拉斯哥昏迷量表评分<8,小儿死亡风险量表平均评分为20(范围10 - 27)。
1例患者术后48小时死于持续性高ICP和循环衰竭。6个月后,根据格拉斯哥预后量表评分,3例患者恢复良好,2例患者恢复但有中度残疾,1例患者有严重残疾。根据小儿总体表现分类量表,4例患者评分为2(轻度残疾),1例评分为3(中度残疾),1例评分为4(重度残疾)。5例患者重返学校并恢复正常生活。
作者发现减压颅骨切除术对儿童是一种有效且挽救生命的技术。该手术应纳入非创伤性颅内高压的治疗手段中。