非肥胖糖尿病（NOD）小鼠中与MHC连锁的1型糖尿病易感性的同源基因定位：至少有两个基因对Idd16效应有影响。

Congenic mapping of the MHC-linked susceptibility to type 1 diabetes in the NOD mouse: at least two genes contribute to the Idd16 effect.

作者信息

Hiromine Yoshihisa, Fujisawa Tomomi, Noso Shinsuke, Babaya Naru, Kawabata Yumiko, Ikegami Hiroshi

机构信息

Department of Endocrinology, Metabolism, and Diabetes, Kinki University School of Medicine, Osaka, Japan.

出版信息

Ann N Y Acad Sci. 2008 Dec;1150:90-2. doi: 10.1196/annals.1447.019.

DOI:10.1196/annals.1447.019

PMID:19120274

Abstract

Major histocompatibility complex (MHC)-linked susceptibility to type 1 diabetes consists of multiple components. Previous studies with NOD mice congenic for the MHC from a sister strain, the CTS mouse, mapped Idd16, a second component of MHC-linked susceptibility to type 1 diabetes, in the region adjacent to, but distinct from Idd1 in the class II region. In this study, three lines of subcongenic strains were established from the original congenic strain. Phenotypic analysis of the strains indicated that MHC-linked susceptibility to type 1 diabetes consists of at least three components: Idd1, Idd16.2 adjacent to Idd1, and Idd16.1 telomeric to Idd16.2.

摘要

主要组织相容性复合体（MHC）相关的1型糖尿病易感性由多个成分组成。先前对来自姐妹品系CTS小鼠的MHC基因座同源的NOD小鼠进行的研究，将Idd16（MHC相关的1型糖尿病易感性的第二个成分）定位在II类区域中与Idd1相邻但不同的区域。在本研究中，从原始同源品系建立了三系亚同源品系。对这些品系的表型分析表明，MHC相关的1型糖尿病易感性至少由三个成分组成：Idd1、与Idd1相邻的Idd16.2以及位于Idd16.2端粒方向的Idd16.1。