Lanier Lewis L
Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143-0414, USA.
Immunol Rev. 2009 Jan;227(1):150-60. doi: 10.1111/j.1600-065X.2008.00720.x.
The DAP10 and DAP12 signaling subunits are highly conserved in evolution and associate with a large family of receptors in hematopoietic cells, including dendritic cells, plasmacytoid dendritic cells, neutrophils, basophils, eosinophils, mast cells, monocytes, macrophages, natural killer cells, and some B and T cells. Some receptors are able to associate with either DAP10 or DAP12, which contribute unique intracellular signaling functions. Studies of humans and mice deficient in these signaling subunits have provided surprising insights into the physiological functions of DAP10 and DAP12, demonstrating that they can either activate or inhibit immune responses. DAP10- and DAP12-associated receptors have been shown to recognize both host-encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses.
DAP10和DAP12信号亚基在进化过程中高度保守，并与造血细胞中的一大类受体相关联，这些造血细胞包括树突状细胞、浆细胞样树突状细胞、中性粒细胞、嗜碱性粒细胞、嗜酸性粒细胞、肥大细胞、单核细胞、巨噬细胞、自然杀伤细胞以及一些B细胞和T细胞。一些受体能够与DAP10或DAP12结合，它们具有独特的细胞内信号传导功能。对缺乏这些信号亚基的人类和小鼠的研究，为深入了解DAP10和DAP12的生理功能提供了惊人的见解，表明它们既可以激活也可以抑制免疫反应。已证明与DAP10和DAP12相关的受体既能识别宿主编码的配体，也能识别微生物病原体编码的配体，这表明它们在先天免疫反应中起重要作用。
