Petoumenou Evangelia, Arndt Martin, Keilig Ludger, Reimann Susanne, Hoederath Hildegard, Eliades Theodore, Jäger Andreas, Bourauel Christoph
Department of Orthodontics, Dental Clinic, University of Bonn, Bonn, Germany.
Am J Orthod Dentofacial Orthop. 2009 Jan;135(1):59-65. doi: 10.1016/j.ajodo.2006.12.018.
The purpose of this study was to examine whether nickel-titanium (Ni-Ti) archwires cause an increase of nickel concentration in the saliva of 18 orthodontic patients to estimate the possible risk of these archwires in patients who have nickel hypersensitivity.
Saliva samples were collected before orthodontic treatment, after placement of the bands and brackets, 2 weeks later and before placing the Ni-Ti archwires, immediately after placing the Ni-Ti archwires, 4 weeks after placing the wires, and 8 weeks after placing the wires.
By using mass spectrometry, no statistically significant differences were found in the nickel concentrations in the samples taken without appliances, in those obtained 2 weeks after placement of the bands and brackets, and 4 and 8 weeks after placement of the archwires. Samples taken immediately after placement of the bands and brackets and the Ni-Ti archwires showed slight but significant increases in nickel concentration of 78 and 56 microg per liter, respectively, compared with the pretreatment value of 34 microg per liter.
Nickel leaching occurred after placement of the bands and brackets and after placement of the Ni-Ti archwires, associated with an increase of the nickel ion concentration in the patient's saliva. This effect decreased within 10 weeks.
本研究的目的是检测镍钛（Ni-Ti）弓丝是否会导致18名正畸患者唾液中镍浓度升高，以评估这些弓丝对镍过敏患者可能存在的风险。
在正畸治疗前、放置带环和托槽后、2周后以及放置Ni-Ti弓丝前、放置Ni-Ti弓丝后立即、放置弓丝4周后和8周后采集唾液样本。
通过质谱分析，在未使用矫治器时采集的样本、放置带环和托槽2周后以及放置弓丝4周和8周后采集的样本中，镍浓度没有统计学上的显著差异。与每升34微克的治疗前值相比，放置带环和托槽后以及放置Ni-Ti弓丝后立即采集的样本中镍浓度分别略有但显著升高，达到每升78微克和56微克。
放置带环和托槽后以及放置Ni-Ti弓丝后会发生镍浸出，这与患者唾液中镍离子浓度升高有关。这种影响在10周内减弱。
