细胞因子基因的微小RNA调控
miRNA regulation of cytokine genes.
作者信息
Asirvatham Ananthi J, Magner William J, Tomasi Thomas B
机构信息
Roswell Park Cancer Institute, Laboratory of Molecular Medicine, Department of Immunology, Elm & Carlton Streets, Buffalo, NY 14263, USA.
出版信息
Cytokine. 2009 Feb;45(2):58-69. doi: 10.1016/j.cyto.2008.11.010. Epub 2009 Jan 1.
Abstract
In this review we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs. The post-transcriptional regulation of cytokine genes via the destabilizing activity of AU-rich elements [AREs] and miRNAs is a pre-requisite for regulating the half-life of many cytokines and achieving the temporal and spatial distributions required for regulation of these genes.
摘要
在本综述中，我们讨论了细胞因子基因调控的具体实例，并着重关注一种涉及通过微小RNA（miRNA）进行转录后调控的新机制。通过富含AU元件[AREs]和miRNA的去稳定化活性对细胞因子基因进行转录后调控，是调节许多细胞因子半衰期并实现这些基因调控所需的时空分布的先决条件。
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