Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Wiley Interdiscip Rev RNA. 2010 Jul-Aug;1(1):60-80. doi: 10.1002/wrna.1. Epub 2010 May 6.
The outcome of an inflammatory response depends upon the coordinated regulation of a variety of both pro-inflammatory and anti-inflammatory cytokines and other proteins. Regulation of these inflammation mediators can occur at multiple levels, including transcription, mRNA translation, post-translational modifications, and mRNA degradation. Post-transcriptional regulation has been shown to play an important role in controlling the expression of these mediators, allowing for normal initiation and resolution of the inflammatory response. Many inflammatory mediators have unstable mRNAs due, in part, to the presence of AU-rich elements in their 3'-untranslated regions. Increasing numbers of RNA-binding proteins have been identified that can bind to these AU-rich elements and then regulate the stability and/or translation of the mRNA. This review summarizes current knowledge about the role of several RNA-binding proteins that act through AU-rich elements to post-transcriptionally regulate the biosynthesis of proteins involved in inflammation.
炎症反应的结果取决于多种促炎和抗炎细胞因子和其他蛋白质的协调调节。这些炎症介质的调节可以在多个水平上发生，包括转录、mRNA 翻译、翻译后修饰和 mRNA 降解。已经表明，转录后调节在控制这些介质的表达中起着重要作用，允许炎症反应的正常启动和解决。许多炎症介质的 mRNA 不稳定，部分原因是其 3'-非翻译区存在富含 AU 的元件。已经鉴定出越来越多的 RNA 结合蛋白，它们可以与这些富含 AU 的元件结合，然后调节 mRNA 的稳定性和/或翻译。这篇综述总结了目前关于几种 RNA 结合蛋白的作用的知识，这些蛋白通过富含 AU 的元件发挥作用，从而对参与炎症的蛋白质的生物合成进行转录后调节。
