孕中期甲状腺刺激激素和游离甲状腺素的方法特异性参考区间
Method specific second-trimester reference intervals for thyroid-stimulating hormone and free thyroxine.
作者信息
Silvio Rechelle, Swapp Karly J, La'ulu Sonia L, Hansen-Suchy Kara, Roberts William L
机构信息
Department of Clinical Laboratory Sciences, Weber State University, Ogden, UT, USA.
出版信息
Clin Biochem. 2009 May;42(7-8):750-3. doi: 10.1016/j.clinbiochem.2008.12.004. Epub 2008 Dec 24.
OBJECTIVE
To determine second trimester reference intervals for TSH and FT4.
DESIGN
Samples from 3102 subjects were tested for TPO and Tg antibodies.
METHODS
Elecsys E170 reference intervals for TSH and FT4 were determined using antibody-negative samples.
RESULTS
Second trimester reference intervals for TSH and FT4 were 0.18-4.07 mIU/L and 9.5-15.8 pmol/L, respectively. The Elecsys E170 TSH results were positively biased compared to ARCHITECT i2000(SR) results for these same samples.
CONCLUSIONS
Method-specific reference intervals are required for TSH and FT4.
目的
确定孕中期促甲状腺激素（TSH）和游离甲状腺素（FT4）的参考区间。
设计
对3102名受试者的样本进行甲状腺过氧化物酶（TPO）和甲状腺球蛋白（Tg）抗体检测。
方法
使用抗体阴性样本确定TSH和FT4的电化学发光免疫分析仪E170参考区间。
结果
孕中期TSH和FT4的参考区间分别为0.18 - 4.07 mIU/L和9.5 - 15.8 pmol/L。对于这些相同样本，与化学发光免疫分析仪ARCHITECT i2000(SR)的结果相比，电化学发光免疫分析仪E170的TSH结果存在正偏差。
结论
TSH和FT4需要特定方法的参考区间。
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