Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
Environ Health. 2013 Sep 8;12(1):76. doi: 10.1186/1476-069X-12-76.
Perfluoroalkyl substances (PFASs) are a group of highly persistent chemicals that are widespread contaminants in wildlife and humans. Exposure to PFAS affects thyroid homeostasis in experimental animals and possibly in humans. The objective of this study was to examine the association between plasma concentrations of PFASs and thyroid stimulating hormone (TSH) among pregnant women.
A total of 903 pregnant women who enrolled in the Norwegian Mother and Child Cohort Study from 2003 to 2004 were studied. Concentrations of thirteen PFASs and TSH were measured in plasma samples collected around the 18th week of gestation. Linear regression models were used to evaluate associations between PFASs and TSH.
Among the thirteen PFASs, seven were detected in more than 60% of samples and perfluorooctane sulfonate (PFOS) had the highest concentrations (median, 12.8 ng/mL; inter-quartile range [IQR], 10.1 -16.5 ng/mL). The median TSH concentration was 3.5 (IQR, 2.4 - 4.8) μIU/mL. Pregnant women with higher PFOS had higher TSH levels. After adjustment, with each 1 ng/mL increase in PFOS concentration, there was a 0.8% (95% confidence interval: 0.1%, 1.6%) rise in TSH. The odds ratio of having an abnormally high TSH, however, was not increased, and other PFASs were unrelated to TSH.
Our results suggest an association between PFOS and TSH in pregnant women that is small and may be of no clinical significance.
全氟烷基物质（PFASs）是一组高度持久的化学物质，广泛存在于野生动物和人类的环境污染物中。实验动物暴露于 PFAS 会影响甲状腺内稳态，而人类可能也会受到影响。本研究的目的是检验孕妇血液中 PFAS 浓度与促甲状腺激素（TSH）之间的相关性。
共有 903 名孕妇参加了 2003 年至 2004 年期间的挪威母亲和儿童队列研究。在妊娠第 18 周左右采集孕妇的血浆样本，检测了 13 种 PFAS 和 TSH 的浓度。采用线性回归模型评估了 PFAS 与 TSH 之间的关系。
在 13 种 PFAS 中，有 7 种物质在 60%以上的样本中被检出，其中全氟辛烷磺酸（PFOS）的浓度最高（中位数 12.8ng/mL，四分位距[IQR]：10.1-16.5ng/mL）。TSH 的中位数浓度为 3.5（IQR：2.4-4.8）μIU/mL。PFOS 浓度较高的孕妇 TSH 水平较高。校正后，PFOS 浓度每增加 1ng/mL，TSH 水平上升 0.8%（95%置信区间：0.1%，1.6%）。然而，TSH 异常升高的比值比没有增加，其他 PFAS 与 TSH 无关。
我们的研究结果表明，孕妇血液中 PFOS 与 TSH 之间存在相关性，但相关性很小，可能没有临床意义。
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