皮肤恶性黑色素瘤的产前危险因素：对1950年至2002年出生的2594783名丹麦人的随访
Prenatal risk factors for cutaneous malignant melanoma: follow-up of 2,594,783 Danes born from 1950 to 2002.
作者信息
Olesen Anne Vingaard, Parner Erik Thorlund, Mortensen Preben Bo, Sørensen Henrik Toft, Olsen Jørn
机构信息
Department of Epidemiology, University of Aarhus, Denmark.
出版信息
Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):155-61. doi: 10.1158/1055-9965.EPI-08-0294.
The incidence of cutaneous malignant melanoma has increased in young adults, specifically in Denmark. In this study, we examined the risk of cutaneous malignant melanoma in relation to prenatal markers of hormone levels and to family-related risk factors. The study was based on a follow-up of 2,594,783 Danes born from 1950 to 2002. Occurrence of possible hormone-related cancers among family members and indicators of abnormal prenatal hormone levels were not associated with cutaneous malignant melanoma risk, whereas family size and mother's age at first birth were significant risk factors for cutaneous malignant melanoma in offspring.
皮肤恶性黑色素瘤的发病率在年轻人中有所上升，丹麦的情况尤为明显。在本研究中，我们调查了与激素水平的产前标志物以及与家族相关的风险因素相关的皮肤恶性黑色素瘤风险。该研究基于对1950年至2002年出生的2,594,783名丹麦人的随访。家庭成员中可能与激素相关的癌症的发生情况以及产前激素水平异常的指标与皮肤恶性黑色素瘤风险无关，而家庭规模和母亲首次生育时的年龄是后代患皮肤恶性黑色素瘤的重要风险因素。
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