Langagergaard Vivian, Puho Erzsebet H, Lash Timothy L, Nørgård Bente, Sørensen Henrik T
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Melanoma Res. 2007 Feb;17(1):31-6. doi: 10.1097/CMR.0b013e3280124749.
Several factors may affect birth outcome in women with cutaneous malignant melanoma. We examined whether maternal cutaneous malignant melanoma affects birth outcome (preterm birth, low birth weight at term, stillbirth, congenital abnormalities, mean birth weight, and male proportion of newborns) in a nationwide cohort study of 1059 births from 1973 to 2002 to women with cutaneous melanoma, compared with 50,794 births from a cohort of mothers without cancer. We found no increased risk of adverse birth outcome for the 620 newborns born to women with a diagnosis of melanoma before pregnancy or the 88 newborns born to women diagnosed during pregnancy. Among 351 births of women diagnosed with melanoma within 2 years from the time of delivery, the prevalence odds ratio of stillbirth was 4.6 (95% confidence interval: 1.7; 12). This estimate was, however, based on only five stillbirths in the exposed group and was an unexpected finding. With this exception, our data suggest no substantially increased risk of adverse birth outcome for women with melanoma.
多种因素可能影响皮肤恶性黑色素瘤女性的分娩结局。在一项全国性队列研究中，我们比较了1973年至2002年间1059例皮肤黑色素瘤女性的分娩情况与50794例无癌症母亲队列的分娩情况，以研究母亲皮肤恶性黑色素瘤是否会影响分娩结局（早产、足月低出生体重、死产、先天性异常、平均出生体重和新生儿男性比例）。我们发现，孕前被诊断为黑色素瘤的女性所生的620例新生儿，以及孕期被诊断为黑色素瘤的女性所生的88例新生儿，其不良分娩结局风险并未增加。在分娩后2年内被诊断为黑色素瘤的女性的351例分娩中，死产的患病优势比为4.6（95%置信区间：1.7；12）。然而，这一估计仅基于暴露组中的5例死产，是一个意外发现。除了这一例外情况，我们的数据表明黑色素瘤女性出现不良分娩结局的风险没有大幅增加。
