Xiao P, Bahr B A, Staubli U, Vanderklish P W, Lynch G
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
Neuroreport. 1991 Aug;2(8):461-4. doi: 10.1097/00001756-199108000-00013.
Slices of hippocampus were incubated with Arg-Gly-Asp (RGD) peptides known to block members of the integrin class of matrix receptors. Though the peptides caused no detectable difference in the amount of long-term potentiation (LTP) expressed in the CA1 field 1-2 min after induction with high frequency stimulation, they did produce a reversible, dose dependent decay of LTP over a period of 40 min. This effect was not obtained with various non-RGD control peptides. These results suggest that stabilization of LTP requires adhesive interactions via specific matrix recognition sites, whereas induction and expression do not.
将海马体切片与已知可阻断整合素类基质受体成员的精氨酸-甘氨酸-天冬氨酸（RGD）肽一起孵育。尽管在用高频刺激诱导后1-2分钟，这些肽在CA1区表达的长时程增强（LTP）量上没有引起可检测到的差异，但它们确实在40分钟的时间内产生了LTP的可逆的、剂量依赖性衰减。用各种非RGD对照肽未获得这种效果。这些结果表明，LTP的稳定需要通过特定的基质识别位点进行粘附相互作用，而诱导和表达则不需要。
