枝霉素，一种来自共生链霉菌属的多烯过氧化物
Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp.
作者信息
Oh Dong-Chan, Scott Jarrod J, Currie Cameron R, Clardy Jon
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Org Lett. 2009 Feb 5;11(3):633-6. doi: 10.1021/ol802709x.
Abstract
A mutualist actinomycete of the southern pine beetle, Dendroctonus frontalis, produces a polyene peroxide with pronounced antifungal activity. Its structure, absolute configuration, and biological activity were determined by spectral analysis, chemical modification followed by the modified Mosher method, and growth inhibitory assays, respectively.
摘要
南方松材线虫（Dendroctonus frontalis）的一种共生放线菌产生了一种具有显著抗真菌活性的多烯过氧化物。分别通过光谱分析、化学修饰后采用改良的莫舍尔方法以及生长抑制试验确定了其结构、绝对构型和生物活性。
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