Lokhandwala M F, Pariani H K, Buckley J P, Jandhyala B S
Eur J Pharmacol. 1977 Mar 21;42(2):107-12. doi: 10.1016/0014-2999(77)90349-1.
I.v. administration of (--)-delta9-trans-tetrahydrocannabinol (delta 9-THC) to chloralose-anesthetized cats produced a decrease in blood pressure and heart rate. Studies conducted to investigate the mechanism of these changes revealed that the hypotensive and bradycardic effects of delta 9-THC (0.1 mg/kg, i.v.) could be significantly antagonized following intraventricular (i.v.t.) perfusion with alpha-adrenergic receptor blocking agent phentolamine, while a larger dose of delta 9-THC (0.25 mg/kg, i.v.) still produced significant hypotension and bradycardia. I.v.t. perfusion of phentolamine (100 mug/min for 30 min) caused a fall in blood pressure and heart rate which were reversible and produced blockade of central alpha-adrenergic receptors. These results provide evidence for the involvement of central alpha-adrenergic receptors in the hypotensive and bradycardic actions of delta 9-THC and indicate that other receptor mechanisms may also be involved in mediating these responses observed following administration of delta 9-THC.
给用氯醛糖麻醉的猫静脉注射（-）-Δ⁹-反式-四氢大麻酚（Δ⁹-THC）会导致血压和心率下降。为研究这些变化的机制而进行的研究表明，在用α-肾上腺素能受体阻断剂酚妥拉明进行脑室内（i.v.t.）灌注后，Δ⁹-THC（0.1毫克/千克，静脉注射）的降压和心动过缓作用可被显著拮抗，而较大剂量的Δ⁹-THC（0.25毫克/千克，静脉注射）仍会产生显著的低血压和心动过缓。脑室内灌注酚妥拉明（100微克/分钟，持续30分钟）会导致血压和心率下降，这种下降是可逆的，并会阻断中枢α-肾上腺素能受体。这些结果为中枢α-肾上腺素能受体参与Δ⁹-THC的降压和心动过缓作用提供了证据，并表明其他受体机制也可能参与介导在给予Δ⁹-THC后观察到的这些反应。
