干扰素β-1a过敏的脱敏治疗：一例报告

Desensitization in interferon-beta1a allergy: a case report.

作者信息

Fusun Kalpaklioglu Ayse, Baccioglu Kavut Ayse, Erdemoglu Ali Kemal

机构信息

Department of Allergic Diseases, Kirikkale University, Pak Sokak No. 3/100, Portakal Cicegi Sokak, Cankaya, Ankara TR-06690, Turkey.

出版信息

Int Arch Allergy Immunol. 2009;149(2):178-80. doi: 10.1159/000189203. Epub 2009 Jan 6.

DOI:10.1159/000189203

PMID:19127077

Abstract

We report a 41-year-old patient with multiple sclerosis (MS) who was successfully desensitized after she developed non-injection-site urticaria and angioedema due to interferon (IFN)-beta1a. Although a few cases of urticaria and anaphylaxis have been reported in the literature, to our knowledge this is the first report of a successful desensitization with IFN-beta1a. Desensitization with IFN-beta1a allowed us to continue with the administration of interferon-beta, which is a mainstay in treatment for MS.

摘要

我们报告了一名41岁的多发性硬化症（MS）患者，该患者在因注射β-干扰素1a出现非注射部位荨麻疹和血管性水肿后成功脱敏。虽然文献中已报道了几例荨麻疹和过敏反应病例，但据我们所知，这是首例使用β-干扰素1a成功脱敏的报告。β-干扰素1a脱敏使我们能够继续使用β-干扰素进行治疗，而β-干扰素是MS治疗的主要药物。