Isingrini Elsa, Desmidt Thomas, Belzung Catherine, Camus Vincent
UMR INSERM U & CNRS FRE, CHRU de Tours, France.
Curr Opin Investig Drugs. 2009 Jan;10(1):46-55.
Depression and Alzheimer's disease (AD) are among the most prevalent mental disorders in the elderly. Strong evidence suggests that vascular diseases and vascular risk factors are associated with both depression and AD, and could partially explain the coexistence or the concurrent onset of these two diseases. In particular, endothelial dysfunction appears to play a critical role in the neurobiology of depression and amyloid deposition in the brains of patients with AD. Antidepressants have a significant impact on endothelial function. In addition, several drugs used to treat vascular disease or vascular risk factors, such as calcium-channel blockers, angiotensin-converting enzyme inhibitors and statins, have, to variable extents, significant clinical effects on depressive symptomatology or amyloid deposition in AD. Furthermore, preclinical and clinical data suggest that the nitric oxide and VEGF signaling pathways may be of value for the treatment of depression and AD.
抑郁症和阿尔茨海默病（AD）是老年人中最常见的精神障碍。有力证据表明，血管疾病和血管危险因素与抑郁症和AD均相关，并且可以部分解释这两种疾病的共存或并发。特别是，内皮功能障碍似乎在抑郁症的神经生物学以及AD患者大脑中的淀粉样蛋白沉积中起关键作用。抗抑郁药对内皮功能有重大影响。此外，几种用于治疗血管疾病或血管危险因素的药物，如钙通道阻滞剂、血管紧张素转换酶抑制剂和他汀类药物，在不同程度上对AD的抑郁症状或淀粉样蛋白沉积具有显著的临床效果。此外，临床前和临床数据表明，一氧化氮和VEGF信号通路可能对抑郁症和AD的治疗具有价值。
