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温针艾灸对绝经后骨质疏松症患者骨密度及骨代谢生化指标的影响

[Effects of warm needle moxibustion on bone mass density and biochemical indexes of bone metabolism in patients of postmenopausal osteoporosis].

作者信息

Zhao Li-hua, Nong Ze-ning, Zhong Xuan, Pang Yong, Liang Jin-song, Li Xiao-dong, Ye Fang-wu

机构信息

Department of Acupuncture, The First Affiliated Hospital of Guangxi University of TCM, Nanning 530023, China.

出版信息

Zhongguo Zhen Jiu. 2008 Dec;28(12):897-900.

Abstract

OBJECTIVE

To compare therapeutic effects of warm needle moxibustion and medication on osteoporosis and to study the mechanism.

METHODS

Forty cases were randomly divided into an acupuncture group and a medication group, 20 cases in each group. The acupuncture group was treated by warm needle moxibustion at Dazhu (BL 11), Ganshu (BL 18), Shenshu (BL 23), Zusanli (ST 36), Yanglingquan (GB 34) etc. once other day, for 3 months; and the medication group was treated by oral administration of tablet Caltrate with Vit D2 for 3 months. The changes of bone mass density (BMD), estradiol (E2), osteocalcin (bone growth protein, BGP), urine calcium/creatinine (Ca/Cr) in the two groups before and after treatment and therapeutic effects were investigated.

RESULTS

After treatment, BMD significantly increased (P<0.05, P<0.01) in the acupuncture group and did not signifi cantly changed in the medication group (P>0.05) with a significant difference between the two groups (P<0.05). After treatment E2 level significantly increased as compared with before treatment in both of groups (P<0.01); after treatment BGP significantly decreased as compared with before treatment in both of groups (P<0.01); after treatment Ca/Cr significantly decreased as compared with before treatment in the acupuncture group (P<0.05) ; af ter treatment, there were significant differences in BGP and Ca/Cr between the two groups (P<0.05 or P<0.01). The clinically controlled rate in the acupuncture group and in the medication group were 35.0%, 5.0%, respectively, the therapeutic effect of the acupuncture group being better than that of the medication group (P<0.01).

CONCLUSION

The therapeutic effect of warm needle moxibustion on osteoporosis is better than that of oral administration of tablet Caltrate with Vit D2 and it can increase levels of hormones and delay bone loss. It is an effective method for preventing and treating postmenopausal osteoporosis.

摘要

目的

比较温针艾灸与药物治疗骨质疏松症的疗效并探讨其机制。

方法

将40例患者随机分为针刺组和药物组,每组20例。针刺组取大杼(BL11)、肝俞(BL18)、肾俞(BL23)、足三里(ST36)、阳陵泉(GB34)等穴位,隔日温针艾灸1次,共治疗3个月;药物组口服维D2钙尔奇片治疗3个月。观察两组治疗前后骨密度(BMD)、雌二醇(E2)、骨钙素(骨生长蛋白,BGP)、尿钙/肌酐(Ca/Cr)的变化及临床疗效。

结果

治疗后,针刺组BMD显著升高(P<0.05,P<0.01),药物组BMD无显著变化(P>0.05),两组比较差异有统计学意义(P<0.05)。两组治疗后E2水平均较治疗前显著升高(P<0.01);两组治疗后BGP水平均较治疗前显著降低(P<0.01);针刺组治疗后Ca/Cr较治疗前显著降低(P<0.05);两组治疗后BGP、Ca/Cr比较差异有统计学意义(P<0.05或P<0.01)。针刺组和药物组的临床控制率分别为35.0%、5.0%,针刺组疗效优于药物组(P<0.01)。

结论

温针艾灸治疗骨质疏松症的疗效优于口服维D2钙尔奇片,可提高激素水平,延缓骨质流失,是防治绝经后骨质疏松症的有效方法。

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