Gøtzsche Peter C
The Nordic Cochrane Centre, Rigshospitalet, Dept 3343, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark.
Trials. 2009 Jan 7;10:2. doi: 10.1186/1745-6215-10-2.
Flaws in research papers are common but it may require arduous detective work to unravel them. Checklists are helpful, but many inconsistencies will only be revealed through repeated cross-checks of every little detail, just like in a crime case. As a major deterrent for dishonesty, raw data from all trials should be posted on a public website. This would also make it much easier to detect errors and flaws in publications, and it would allow many research projects to be performed without collecting new data. The prevailing culture of secrecy and ownership to data is not in the best interests of patients.
研究论文中的缺陷很常见,但要发现这些缺陷可能需要艰苦的调查工作。核对清单很有帮助,但许多不一致之处只有通过对每个细节进行反复核对才能发现,就像在犯罪案件中一样。作为对不诚实行为的主要威慑手段,所有试验的原始数据都应发布在公共网站上。这也将使发现出版物中的错误和缺陷变得容易得多,并且将允许许多研究项目在不收集新数据的情况下进行。目前盛行的数据保密和所有权文化不符合患者的最佳利益。