Burns Christopher J, Harte Michael F, Bu Xianyong, Fantino Emmanuelle, Giarrusso Marilena, Joffe Max, Kurek Margarita, Legge Fiona S, Razzino Pasquale, Su Stephen, Treutlein Herbert, Wan Soo San, Zeng Jun, Wilks Andrew F
Cytopia Research Pty Ltd, 576 Swan Street, Richmond, VIC. 3121, Australia.
Bioorg Med Chem Lett. 2009 Feb 15;19(4):1206-9. doi: 10.1016/j.bmcl.2008.12.073. Epub 2008 Dec 25.
A series of 2-(alpha-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.
一系列2-（α-甲基苄基氨基）吡嗪已被证明是FMS酪氨酸受体激酶的有效抑制剂。本文报道了该系列化合物的构效关系研究、建模及合成细节。
