Chalabi N, Bernard-Gallon D J, Bignon Y J, Kwiatkowski F, Agier M, Vidal V, Laplace-Chabaud V, Sylvain-Vidal V, Bertholet V, De Longueville F, Lacroix M, Leclercq G, Remacle J, Sibille C, Zammateo N, Ben Jaafar N, Sefiani A, Ouldim K, Mégarbané K, Jalkh N, Mahfoudh W, Troudi W, Ben Ammar-El Gaïed A, Chouchane L
Département d'Oncogénétique, Centre Jean Perrin, 63011 Clermont-Ferrand Cedex 01, France.
Cancer Genomics Proteomics. 2008 Sep-Oct;5(5):253-61.
In Western countries, breast cancer incidence and mortality are higher than in Mediterranean countries. These differences have been ascribed to environmental factors but also to late-stage diagnostic and biological specific characteristics.
Between September 2002 and September 2005, we collected clinical data by phone counselling 180 French and Mediterranean breast cancer patients and performed microarray experiments.
Characteristics of breast cancer in patients from Lebanon, Tunisia and Morocco were more aggressive (more SBR grade III and positive node invasion) and patients were 10 years younger at diagnosis. Sixteen differentially expressed genes such as MMP9, VEGF, PHB1, BRCA1, TFAP2C, GJA1 and TFF1 were also found. Additionally, an up-regulation of cytokeratins KRT8 and KRT18 may indicate a luminal B subtype in "South" (Lebanon, Tunisia and Morocco) tumors while "North" (France) tumors may more frequently be luminal A type.
This study allowed the identification of specific clinical and transcriptomic parameters in patients from South Mediterranean countries.
在西方国家，乳腺癌的发病率和死亡率高于地中海国家。这些差异归因于环境因素，也归因于晚期诊断和生物学特性。
2002年9月至2005年9月期间，我们通过电话咨询收集了180名法国和地中海地区乳腺癌患者的临床数据，并进行了微阵列实验。
来自黎巴嫩、突尼斯和摩洛哥的患者的乳腺癌特征更具侵袭性（更多SBR III级和阳性淋巴结浸润），且患者诊断时的年龄要小10岁。还发现了16个差异表达基因，如基质金属蛋白酶9（MMP9）、血管内皮生长因子（VEGF）、线粒体外膜转位酶17（PHB1）、乳腺癌1号基因（BRCA1）、转录因子AP - 2γ（TFAP2C）、缝隙连接蛋白α1（GJA1）和三叶因子1（TFF1）。此外，细胞角蛋白KRT8和KRT18的上调可能表明“南方”（黎巴嫩、突尼斯和摩洛哥）肿瘤为管腔B亚型，而“北方”（法国）肿瘤可能更常见为管腔A型。
本研究确定了南地中海国家患者的特定临床和转录组学参数。
