Erdös E G
Fed Proc. 1977 Apr;36(5):1760-5.
The angiotensin I converting enzyme (kininase II; peptidyl dipeptidase; EC3.4.15.1) has a dual function: it converts angiotensin I to angiotensin II and it inactivates bradykinin. Lung, kidney, guinea pig plasma and testicles are among the richest sources of the enzyme. Vascular endothelial cells and bursh borders of renal proximal tubular cells contain high concentrations of the enzyme. The availability of synthetic peptide inhibitors was a great help in establishing the function of converting enzyme in normal and pathological conditions.
血管紧张素I转换酶（激肽酶II；肽基二肽酶；EC3.4.15.1）具有双重功能：它将血管紧张素I转化为血管紧张素II，并使缓激肽失活。肺、肾、豚鼠血浆和睾丸是该酶最丰富的来源之一。血管内皮细胞和肾近端小管细胞的刷状缘含有高浓度的该酶。合成肽抑制剂的出现对确定转换酶在正常和病理条件下的功能有很大帮助。
