Electrophysiological evidence that morphine can exert an antinociceptive effect in a neuropathic state: a study in the ventrobasal thalamus of rats after moderate ligation of one sciatic nerve.
作者信息
Guilbaud G, Benoist J M, Gautron M
机构信息
Institut National de la Santé et de la Recherche Médicale, U.161, Paris, France.
出版信息
Brain Res. 1991 Jun 14;551(1-2):346-50. doi: 10.1016/0006-8993(91)90956-v.
PMID:1913166
Abstract
This study was performed in rats with a mononeuropathy induced by loose ligatures around the common sciatic nerve 2 weeks before the recording session, and exhibiting clear alterations of several pain-related behaviours. Morphine injected intravenously (0.6 and 1 mg/kg) strongly depressed the ventrobasal thalamic neuronal responses to pinch applied to the lesioned or the non-lesioned hindpaw. The effect, comparable on the both sides, was dose-related and reversed by naloxone (0.1 mg/kg i.v.).
摘要
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