微生物药物发现：80年的进展。
Microbial drug discovery: 80 years of progress.
作者信息
Demain Arnold L, Sanchez Sergio
机构信息
Research Institute for Scientists Emeriti, Drew University, Madison, NJ 07940, USA.
出版信息
J Antibiot (Tokyo). 2009 Jan;62(1):5-16. doi: 10.1038/ja.2008.16. Epub 2009 Jan 9.
Abstract
Microbes have made a phenomenal contribution to the health and well-being of people throughout the world. In addition to producing many primary metabolites, such as amino acids, vitamins and nucleotides, they are capable of making secondary metabolites, which constitute half of the pharmaceuticals on the market today and provide agriculture with many essential products. This review centers on these beneficial secondary metabolites, the discovery of which goes back 80 years to the time when penicillin was discovered by Alexander Fleming.
摘要
微生物对全世界人们的健康和福祉做出了巨大贡献。除了产生许多初级代谢产物，如氨基酸、维生素和核苷酸外，它们还能产生次级代谢产物，这些次级代谢产物构成了当今市场上一半的药品，并为农业提供了许多重要产品。本综述聚焦于这些有益的次级代谢产物，其发现可追溯到80年前亚历山大·弗莱明发现青霉素的时代。
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