Farza M, Chéruy A
Laboratoire d'Automatique de Grenoble, UA CNRS 228, Saint Martin d'Héres, France.
Comput Appl Biosci. 1991 Jul;7(3):327-36. doi: 10.1093/bioinformatics/7.3.327.
CAMBIO, a software package devoted to bioprocess modelling, which runs on Apollo computers, is described. This software enables bioengineers to easily and interactively design appropriate mathematical models directly from their perception of the process. CAMBIO provides the user with a set of design symbols and mnemonic icons in order to interactively design a functional diagram. This diagram has to exhibit the most relevant components with their related interactions through biological and physico-chemical reactions. Then, CAMBIO automatically generates the dynamical material balance equations of the process in the form of an algebraic-differential system by taking advantage of the knowledge involved in the functional diagram. The model may be used for control design purpose or completed by kinetics expressions with a view to simulation. CAMBIO offers facilities to generate a simulation model (for coding of kinetics, introducing auxiliary variables, etc.). This model is automatically interfaced with a specialized simulation software which allows an immediate visualization of the process dynamical behaviour under various operational conditions (possibly involving feedback control strategies). An example of an application dealing with yeast fermentation is given.
介绍了一种名为CAMBIO的软件包，它专门用于生物过程建模，可在阿波罗计算机上运行。该软件使生物工程师能够根据对过程的理解轻松且交互式地直接设计合适的数学模型。CAMBIO为用户提供了一组设计符号和助记图标，以便交互式地设计功能图。该图必须展示出最相关的组件及其通过生物和物理化学反应的相关相互作用。然后，CAMBIO利用功能图中涉及的知识，以代数 - 微分系统的形式自动生成过程的动态物料平衡方程。该模型可用于控制设计目的，或通过动力学表达式进行补充以进行模拟。CAMBIO提供了生成模拟模型的工具（用于动力学编码、引入辅助变量等）。该模型会自动与专门的模拟软件接口，该软件允许在各种操作条件下（可能涉及反馈控制策略）立即可视化过程的动态行为。给出了一个处理酵母发酵的应用示例。
