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[妊娠末期小鼠的染色体超放射敏感性]

[Chromosome hyper-radiosensitivity in mice at the end of pregnancy].

作者信息

Ricoul M, Dutrillaux B

机构信息

Laboratoire de Génétique expérimentale, Fontenay-aux-Roses.

出版信息

C R Acad Sci III. 1991;312(13):635-9.

PMID:1913237
Abstract

Irradiation of mice with 2 Gy of gamma-rays at various times of pregnancy induces a threefold increase in the rate of chromosome breaks in spontaneously dividing bone marrow cells from the 16th to 19th days. This high sensitivity disappears shortly after delivery, and it is even possible that a hyposensitivity develops at this time. The causes of this phenomenon remain unknown, but since it occurs shortly after the high increase of oestrogen and progesterone hormones, a direct relationship may exist.

摘要

在怀孕的不同时期用2戈瑞的γ射线照射小鼠,会导致自发分裂的骨髓细胞在第16至19天的染色体断裂率增加两倍。这种高敏感性在分娩后不久就会消失,甚至有可能在此时出现低敏感性。这种现象的原因尚不清楚,但由于它发生在雌激素和孕激素大幅增加之后不久,可能存在直接关系。

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