中医治疗四名亨廷顿舞蹈症患者的情况。
Traditional Chinese medicine on four patients with Huntington's disease.
作者信息
Satoh Takashi, Takahashi Toshiyuki, Iwasaki Koh, Tago Hideaki, Seki Takashi, Yaegashi Nobuo, Tobita Muneshige, Arai Hiroyuki
机构信息
National Yonezawa Hospital, Yonezawa City, Yamagata, Japan.
出版信息
Mov Disord. 2009 Feb 15;24(3):453-5. doi: 10.1002/mds.22447.
Four Huntington's disease (HD) patients were treated with traditional Chinese medicines Yi-Gan San (YGS) and Chaihu-Jia-Longgu-Muli Tan (CLMT) in a cross-over manner. Two patients took YGS for 8 weeks first, and after 4 weeks of washing out, they took CLMT for 8 weeks. Two other patients took these medicines in reverse order. All patients showed a decrease in the Unified Huntington's Disease Rating Scale-motor assessment (from 106.3 +/- 4.7 to 89.6 +/- 5.8 as mean +/- SD, P = 0.0004) by YGS treatment with no extrapiramidal symptoms or changes of cognition or ADL. Our study suggests a possibility of a new treatment for involuntary movements.
4例亨廷顿舞蹈病（HD）患者以交叉方式接受了中药一贯煎（YGS）和柴胡加龙骨牡蛎汤（CLMT）治疗。2例患者先服用YGS 8周，洗脱4周后，再服用CLMT 8周。另外2例患者则以相反顺序服用这些药物。所有患者经YGS治疗后，统一亨廷顿病评定量表运动评估得分均下降（平均±标准差，从106.3±4.7降至89.6±5.8，P = 0.0004），且无锥体外系症状、认知或日常生活活动能力改变。我们的研究提示了一种治疗不自主运动新方法的可能性。
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