磷酸二酯酶-5抑制剂对听力的影响。
Effect of phosphodiesterase-5 inhibitor on hearing.
作者信息
Okuyucu S, Guven O E, Akoglu E, Uçar E, Dagli S
机构信息
Department of Otolaryngology, Mustafa Kemal University School of Medicine, Antakya, Hatay, Turkey.
出版信息
J Laryngol Otol. 2009 Jul;123(7):718-22. doi: 10.1017/S002221510900423X. Epub 2009 Jan 12.
OBJECTIVE
Following a report of sudden hearing loss in a patient taking phosphodiesterase type 5 inhibitor, and a Food and Drug Administration announcement concerning this class of drugs, a study was planned to investigate if ototoxicity occurs in patients using phosphodiesterase 5 inhibitor for erectile dysfunction.
METHODS
Eighteen patients with erectile dysfunction who had been using phosphodiesterase 5 inhibitor were included in the study. Audiometric tests were performed on all patients, between the frequencies 250 and 16,000 Hz, before and 1, 5 and 72 hours after drug ingestion.
RESULTS
Four patients showed a unilateral threshold decrease compatible with ototoxicity criteria; this change was reversible. A statistically significant difference in pre- versus post-drug hearing thresholds was observed in the right ear at 10,000 Hz (p = 0.008). There were no statistically significant hearing threshold differences at any other frequencies (p > 0.05).
CONCLUSION
Although temporary ototoxicity was noted in four patients, we could not find any permanent, deleterious effect of phosphodiesterase type 5 inhibitor on hearing thresholds.
目的
在有患者服用5型磷酸二酯酶抑制剂后出现突发性听力损失的报告以及美国食品药品监督管理局发布有关此类药物的公告后，计划开展一项研究，以调查使用5型磷酸二酯酶抑制剂治疗勃起功能障碍的患者是否会发生耳毒性。
方法
18名一直在使用5型磷酸二酯酶抑制剂的勃起功能障碍患者被纳入该研究。在所有患者摄入药物前以及摄入后1小时、5小时和72小时，对其进行了250至16000赫兹频率范围的听力测试。
结果
4名患者出现符合耳毒性标准的单侧阈值下降；这种变化是可逆的。在10000赫兹时，右耳用药前和用药后的听力阈值存在统计学上的显著差异（p = 0.008）。在其他任何频率下，听力阈值均无统计学上的显著差异（p > 0.05）。
结论
尽管4名患者出现了暂时性耳毒性，但我们未发现5型磷酸二酯酶抑制剂对听力阈值有任何永久性的有害影响。
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