确定预防氨基糖苷类耳毒性的靶点。

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Mol Cell Neurosci. 2022 May;120:103722. doi: 10.1016/j.mcn.2022.103722. Epub 2022 Mar 24.

Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration. Despite their ototoxic side effects, there are currently no approved antidotes. Here we review recent advances in our understanding of aminoglycoside ototoxicity, mechanisms of drug transport, and promising sites for intervention to prevent ototoxicity.

氨基糖苷类抗生素是一类强效抗生素，在全球范围内广泛应用。其使用存在显著的耳毒性风险，可直接导致内耳毛细胞变性。尽管存在耳毒性副作用，但目前尚无批准的解毒剂。本文综述了我们对氨基糖苷类抗生素耳毒性的认识、药物转运机制以及预防耳毒性的有希望的干预靶点方面的最新进展。