[Ib2-IIb期宫颈癌动脉内与静脉内新辅助化疗疗效的比较]

[Comparison of effectiveness between intra-arterial and intra-venous neoadjuvant chemotherapy in stage Ib2-IIb cervical carcinoma].

作者信息

Cao Dong-yan, Yang Jia-xin, Shen Keng, Xiang Yang, Pan Ling-ya, Lang Jing-he, Wu Ming, Huang Hui-fang

机构信息

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2008 Dec;43(12):888-91.

PMID:19134324

Abstract

OBJECTIVE

To compare the effect between intra-arterial and intra-venous neoadjuvant chemotherapy (NACT) in stage Ib2-IIb cervical carcinoma.

METHODS

A retrospective analysis was done on 52 cases of intra-venous NACT and 95 cases of intra-arterial NACT for stage Ib2-IIb cervical carcinoma treated in Peking Union Medical College Hospital from 1999.

RESULTS

The response rate of intra-venous NACT and intra-arterial NACT was 88% (46/52) and 79% (75/95), and the operative rate after NACT was 81% (42/52) and 72% (68/95) respectively (P > 0.05). There were no significant differences in surgery time, blood loss and post-operative morbidity between these two groups. Pathological parametrial positive rate after NACT in arterial group (6%) was significantly lower than that of venous group (50%, P > 0.05). The venous group had very similar recurrence rates (13% vs 17%) and death rates (9% vs 12%) when compared with the arterial group (P > 0.05).

CONCLUSIONS

The intra-arterial and intra-venous NACT for stage Ib2-IIb cervical carcinoma show similar response rate, operative rate and surgical difficulties. Arterial NACT shows a better effect on parametrial infiltration.

摘要

目的

比较动脉内与静脉内新辅助化疗（NACT）用于Ib2-IIb期宫颈癌的疗效。

方法

对1999年以来北京协和医院收治的52例接受静脉内NACT和95例接受动脉内NACT治疗的Ib2-IIb期宫颈癌患者进行回顾性分析。

结果

静脉内NACT和动脉内NACT的有效率分别为88%（46/52）和79%（75/95），NACT后的手术率分别为81%（42/52）和72%（68/95）（P>0.05）。两组在手术时间、失血量和术后发病率方面无显著差异。动脉组NACT后病理宫旁阳性率（6%）显著低于静脉组（50%，P>0.05）。与动脉组相比，静脉组的复发率（13%对17%）和死亡率（9%对12%）非常相似（P>0.05）。