Dubrow R, Flannery J T, Liu W L
Yale University School of Medicine, New Haven, Connecticut 06510.
Cancer. 1991 Oct 15;68(8):1854-8. doi: 10.1002/1097-0142(19911015)68:8<1854::aid-cncr2820680837>3.0.co;2-c.
Time trends in the incidence of malignant melanoma of the anatomic subsites of the upper limb in Connecticut from 1935 to 1984 were examined. Among males, the incidence of melanoma of the hand was stable, in sharp contrast to the 15-fold to 16-fold increase in the upper arm and forearm. Among females, the 3-fold increase in melanoma of the hand was substantially less than the 12-fold to 14-fold increase in the upper arm and forearm. However, melanoma of the dorsal surface of the hand in females increased sevenfold. These results are in partial agreement with the hypothesis that the hand would be relatively resistant to increased melanoma incidence because it has continually been a sun-exposed site over the decades. The results contradict the hypothesis that the rise in incidence would be greater in the upper arm (a usually unexposed site that has received increasing exposure due to changes in recreation and dress habits) than in the forearm (a site of intermediate exposure).
对1935年至1984年康涅狄格州上肢各解剖亚部位恶性黑色素瘤发病率的时间趋势进行了研究。在男性中，手部黑色素瘤的发病率稳定，这与上臂和前臂15倍至16倍的增长形成鲜明对比。在女性中，手部黑色素瘤3倍的增长远低于上臂和前臂12倍至14倍的增长。然而，女性手部背侧的黑色素瘤增加了7倍。这些结果部分支持了这样一种假设，即手部对黑色素瘤发病率增加相对具有抵抗力，因为在过去几十年里它一直是持续暴露于阳光下的部位。这些结果与以下假设相矛盾，即上臂（一个通常未暴露的部位，由于娱乐和着装习惯的变化而受到越来越多的暴露）的发病率上升幅度会比前臂（一个中等暴露部位）更大。
