Bijen Claudia B M, de Bock Geertruida H, ten Hoor Klaske A, Nijman Hans W, Hollema Harry, Mourits Marian J E
Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Gynecol Oncol. 2009 Mar;112(3):521-5. doi: 10.1016/j.ygyno.2008.11.023. Epub 2009 Jan 10.
The presence of cervical involvement is important to establish a rational treatment for endometrial cancer patients. We investigated the value of preoperative endocervical curettage (ECC) in predicting cervical involvement.
Preoperative ECC of 290 patients with clinical stage I epithelial endometrial cancer was compared with histopathology of the uterus.
Amongst all ECCs, 245 (84.5%) were negative and 45 (15.5%) were positive for endometrial cancer. In the uterine specimen, cervical involvement was found in 20% (58/290). PPV and NPV of ECC were 86.7% and 92.2%. False negative and false positive ECC occurred in 6.6% and 2.1%. Of all patients with positive ECC, 46.7% had FIGO stage II disease and 46.7% had extra uterine tumor spread (FIGO III, IV).
ECC is an acceptable diagnostic tool to predict the presence or absence of cervical involvement in early stage endometrial cancer patients.
确定宫颈受累情况对于为子宫内膜癌患者制定合理的治疗方案至关重要。我们研究了术前宫颈刮除术（ECC）在预测宫颈受累方面的价值。
将290例临床I期上皮性子宫内膜癌患者的术前ECC结果与子宫组织病理学结果进行比较。
在所有ECC检查中，245例（84.5%）子宫内膜癌为阴性，45例（15.5%）为阳性。在子宫标本中，发现20%（58/290）存在宫颈受累。ECC的阳性预测值（PPV）和阴性预测值（NPV）分别为86.7%和92.2%。ECC的假阴性和假阳性率分别为6.6%和2.1%。在所有ECC阳性的患者中，46.7%为国际妇产科联盟（FIGO）II期疾病，46.7%有子宫外肿瘤扩散（FIGO III、IV期）。
ECC是预测早期子宫内膜癌患者是否存在宫颈受累的一种可接受的诊断工具。
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