Giannella L, Menozzi G, Di Monte I, Venturini P, De Pace V, Boselli F, Ternelli G, Jasonni V M
Divisione di Ostetricia e Ginecologia, Ospedale C. Magati di Scandiano, Reggio Emilia, Italy.
Minerva Ginecol. 2008 Aug;60(4):273-9.
To investigate a possible relationship between preoperative platelet count and following clinicopathological variables of the endometrial carcinoma: age, stage, histological type, histological grading (G), myometrial invasion, lymphovascular space involvement, cervical involvement, lymph node metastasis. In particular the existence of a possible relationship between elevated preoperative platelet count (=or>300 000 microL) and negative prognostic factors.
The authors analyzed retrospectively 120 patients with endometrial carcinoma underwent to surgery as the initial treatment. All the patients were subjected to radical surgical procedure: peritoneal cytology, total abdominal hysterectomy, bilateral salpingo-oophorectomy, systematic pelvic lymphadenectomy and omentectomy. Blood platelet count was taken from the patients three days prior to the surgery.
The patients with platelet count<300000/microL whom they had a G1, G2, G3 they were respectively the 23.1%, 44.2% and 32.7% versus the 0%, 12.5% and 87.5%, respectively for G1, G2, G3, of the patients with platelet count>300000/microL (P=0.024). Only considering the patients to the stage I of the Federazione Internazionale dei Ginecologi ed Ostetrici (FIGO). The patients with platelet count<300000/microL whom they had a G1, G2, G3 they were respectively the 27.3%, 43.2% and 29.5% versus the 0%, 0% and 100%, respectively for G1, G2, G3, of the patients with platelet count=or>300000/microL (P=0.008). There were no differences respect to age, stage, histological type, myometrial invasion, lymphovascular space involvement and cervical involvement.
Elevated preoperative platelet count, in the patients with endometrial carcinoma, may reflect poor prognostic factor such as higher histological grade. This study allowed to observe: a significant correlation between elevated preoperative platelet count (=or>300000/microL) and tumoral grading (G3) of general population submitted to study; for the patients to the stage I FIGO a more significant correlation between elevated preoperative platelet count (=or>300000/microL) and tumoral grading: the 100% of the patients with platelet count=or>300 000/microL had a histological grading G3.
探讨子宫内膜癌患者术前血小板计数与以下临床病理变量之间的可能关系：年龄、分期、组织学类型、组织学分级（G）、肌层浸润、淋巴血管间隙受累、宫颈受累、淋巴结转移。特别是术前血小板计数升高（=或>300 000/μL）与不良预后因素之间是否存在可能的关系。
作者回顾性分析了120例行手术作为初始治疗的子宫内膜癌患者。所有患者均接受根治性手术：腹腔细胞学检查、全腹子宫切除术、双侧输卵管卵巢切除术、系统性盆腔淋巴结清扫术和大网膜切除术。术前三天采集患者的血小板计数。
血小板计数<300000/μL的患者中，G1、G2、G3级患者分别占23.1%、44.2%和32.7%，而血小板计数>300000/μL的患者中，G1、G2、G3级患者分别占0%、12.5%和87.5%（P=0.024）。仅考虑国际妇产科联合会（FIGO）I期患者。血小板计数<300000/μL的患者中，G1、G2、G3级患者分别占27.3%、43.2%和29.5%，而血小板计数=或>300000/μL的患者中，G1、G2、G3级患者分别占0%、0%和100%（P=0.008）。在年龄、分期、组织学类型、肌层浸润、淋巴血管间隙受累和宫颈受累方面无差异。
子宫内膜癌患者术前血小板计数升高可能反映不良预后因素，如较高的组织学分级。本研究观察到：在接受研究的总体人群中，术前血小板计数升高（=或>300000/μL）与肿瘤分级（G3）之间存在显著相关性；对于FIGO I期患者，术前血小板计数升高（=或>300000/μL）与肿瘤分级之间的相关性更为显著：血小板计数=或>300 000/μL的患者中有100%的组织学分级为G3。
