Hruban Z, Dubien L H, Glagov S, Getz G S
Department of Pathology, University of Chicago.
J Submicrosc Cytol Pathol. 1991 Jul;23(3):491-500.
Several types of cytoplasmic and nuclear inclusions represent stages in the process of non-lysosomal cytoplasmic degradation. Nonlysosomal degradation takes place in regions where cytoplasmic components are trapped and not accessible to primary and secondary lysosomes. Such trapping occurs within the lumina of the nuclear envelope and of endoplasmic reticulum in the form of inverted vesicles, within the nucleus, within mitochondria and within cavities formed by the process of topolysis in neutral lipid droplets. The concept of the process of nonlysosomal degradation permits dynamic interpretation of various inclusions as the concept of the process of focal cytoplasmic degration (autophagy) leads to dynamic interpretation of the lysosome.
几种类型的细胞质和核内包涵体代表了非溶酶体细胞质降解过程中的不同阶段。非溶酶体降解发生在细胞质成分被困住且初级和次级溶酶体无法接触到的区域。这种被困现象以倒转囊泡的形式发生在核膜和内质网的腔内、细胞核内、线粒体内以及中性脂滴中自溶过程形成的腔内。非溶酶体降解过程的概念允许对各种包涵体进行动态解释，就如同局灶性细胞质降解（自噬）过程的概念导致对溶酶体进行动态解释一样。
