IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
作者信息
Yamada Atsushi, Suzuki Dai, Miyazono Agasa, Oshima Kumiko, Kamiya Akihide, Zhao Baohong, Takami Masamichi, Donnelly Raymond P, Itabe Hiroyuki, Yamamoto Matsuo, Kimura Shioko, Kamijo Ryutaro
机构信息
Department of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan.
出版信息
Biochem Biophys Res Commun. 2009 Feb 20;379(4):964-8. doi: 10.1016/j.bbrc.2008.12.187. Epub 2009 Jan 9.
Abstract
STAT1 mediates Interferon (IFN)-dependent positive and negative regulation of inflammatory gene expression in lung. In this study, we examined the effect of IFN-gamma on the expression of SCGB3A1 which is thought to play crucial roles in inflammation and epithelial cell differentiation in lung. We found that expression of SCGB3A1 was down-regulated by IFN-gamma in a time- and dose-dependent manner in the murine transformed Clara Cells (mtCC) line. IFN-gamma induced the phosphorylation of STAT1, which binds to a STAT-binding element (SBE) in the SCGB3A1 gene promoter, leading to decreased transcriptional activation of this gene.
摘要
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