小型DNA肿瘤病毒：生物医学科学的重要贡献者。
Small DNA tumor viruses: large contributors to biomedical sciences.
作者信息
Howley Peter M, Livingston David M
机构信息
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Virology. 2009 Feb 20;384(2):256-9. doi: 10.1016/j.virol.2008.12.006. Epub 2009 Jan 10.
Abstract
Studies of the small DNA tumor viruses (the polyomaviruses, the adenoviruses and the papillomaviruses) have led to fundamental discoveries that have advanced our understanding of basic mammalian cell molecular biology processes such as transcription and DNA replication, uncovered pathways and genes often perturbed in human cancer, and identified bona fide human cancer viruses. In this article we examine the many contributions that have come from the small DNA tumor virus field and provide a recounting of some of the major landmark discoveries.
摘要
对小型DNA肿瘤病毒（多瘤病毒、腺病毒和乳头瘤病毒）的研究带来了一些重要发现，这些发现推动了我们对基本哺乳动物细胞分子生物学过程（如转录和DNA复制）的理解，揭示了在人类癌症中经常受到干扰的途径和基因，并鉴定出了真正的人类癌症病毒。在本文中，我们探讨了小型DNA肿瘤病毒领域所做出的诸多贡献，并回顾了一些具有里程碑意义的重大发现。
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