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[The role of a mitochondrial palmitate/Ca(2+)-activated pore in palmitate-induced apoptosis].

作者信息

Belosludtsev K N, Belosludtseva N V, Mironova G D

出版信息

Biofizika. 2008 Nov-Dec;53(6):967-71.

PMID:19137679
Abstract

Evidence for the possible involvement of the mitochondrial cyclosporin A-insensitive palmitate/Ca(2+)-activated pore in the apoptotic process is presented. It has been established that the opening of palmitate/Ca(2+)-activated pore results in high-amplitude swelling of mitochondria and the release of apoptosis-induced factor from organelles. These processes are accompanied by a transitory small decrease of membrane potential, which recovers in 1 min. The possible role of palmitate/Ca(2+)-activated pore in the induction of palmitate-activated apoptosis is discussed.

摘要

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引用本文的文献

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Mitochondrial Cyclosporine A-Independent Palmitate/Ca-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity.线粒体环孢素 A 非依赖性棕榈酸/钙诱导的通透性转换孔（PA-mPT 孔）及其在线粒体功能和保护中的作用，防止钙超载和谷氨酸毒性。
Cells. 2021 Jan 11;10(1):125. doi: 10.3390/cells10010125.