Gorbacheva Iu V, Romadanova Iu A, Solomakhina M A, Popova O P, Voloshchuk I N
Arkh Patol. 2008 Sep-Oct;70(5):12-6.
The expression of E-cadherin and beta-catenin in the eutopic and ectopic endometrium was studied in 40 patients with adenomyosis and 12 without this condition, by using an immunohistochemical test and enzyme immunoassay. There was increased expression of E-cadherin and beta-catenin in the eutopic and ectopic endometrium in adenomyosis. The cytoplasmic expression of beta-catenin was also revealed in the smooth muscle cells surrounding the foci of adenomyosis. The E-cadherin concentration measured by enzyme immunoassay was significantly higher in the endometrium and myometrium of patients with adenomyosis than in the controls. There was a higher expression of this protein with a longer duration of the disease. Thus, the formation of ectopic foci in adenomyosis may be argued to be unassociated with the decreased adhesion of epithelial cells. On the contrary, the authors documented the enhanced adhesion of epithelial cells in the ectopic foci, which was likely to be adaptive due to the altered microcirculation.
采用免疫组织化学检测和酶免疫测定法，对40例子宫腺肌病患者及12例非子宫腺肌病患者在位及异位子宫内膜中E-钙黏蛋白和β-连环蛋白的表达进行了研究。子宫腺肌病患者在位及异位子宫内膜中E-钙黏蛋白和β-连环蛋白的表达增加。在子宫腺肌病病灶周围的平滑肌细胞中也发现了β-连环蛋白的细胞质表达。酶免疫测定法测得子宫腺肌病患者子宫内膜和肌层中E-钙黏蛋白浓度明显高于对照组。随着病程延长，该蛋白表达更高。因此，可以认为子宫腺肌病中异位病灶的形成与上皮细胞黏附力降低无关。相反，作者记录到异位病灶中上皮细胞黏附力增强，这可能是由于微循环改变而产生的适应性变化。
