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缺血性二尖瓣反流修复术中后内侧乳头肌移位的纠正

Correction of posteromedial papillary muscle displacement in repair of ischemic mitral regurgitation.

作者信息

Marasco Silvana F, Rosenfeldt Franklin L, Lim Hou-Kiat, Mennen Mark, Cairo Sesto, Bain Chris

机构信息

CJOB Department of Cardiothoracic Surgery, The Alfred Hospital, Melbourne, Australia.

出版信息

J Heart Valve Dis. 2008 Nov;17(6):620-7.

Abstract

BACKGROUND AND AIM OF THE STUDY

Ischemic mitral regurgitation is present in a substantial proportion of patients presenting for coronary revascularization. Although patients with even mild to moderate ischemic mitral regurgitation (IMR) have a poorer long-term outcome, mitral valve repair in these cases can be unreliable due to the posterior leaflet tethering that commonly occurs. The aim of this animal-based study was to evaluate a novel technique to effect such a repair.

METHODS

IMR was produced in six greyhound dogs by tying off the circumflex coronary artery; a mitral valve repair was then performed on cardiopulmonary bypass (CPB). Two hitching sutures from the posteromedial papillary muscle (PPM) to the annulus were individually assessed using epicardial echocardiography when the dogs had been weaned off CPB.

RESULTS

Acute dilatation of the heart with PPM displacement and mitral regurgitation were produced in this acute infarct model. Both hitching sutures shortened the distance from the free edge of the posterior leaflet to the PPM tip and reduced its displacement, with a resultant reduction in mitral regurgitation.

CONCLUSION

This simple repair technique may be a useful adjunct to annuloplasty in the treatment of ischemic mitral regurgitation.

摘要

研究背景与目的

在接受冠状动脉血运重建的患者中,相当一部分存在缺血性二尖瓣反流。尽管即使是轻度至中度缺血性二尖瓣反流(IMR)的患者长期预后较差,但由于常见的后叶瓣叶束缚,这些病例中的二尖瓣修复可能不可靠。这项基于动物的研究旨在评估一种实现这种修复的新技术。

方法

通过结扎旋支冠状动脉在6只灵缇犬身上制造IMR;然后在体外循环(CPB)下进行二尖瓣修复。当犬脱离CPB后,使用心外膜超声心动图分别评估从后内侧乳头肌(PPM)到瓣环的两根牵引缝线。

结果

在这个急性梗死模型中产生了心脏急性扩张伴PPM移位和二尖瓣反流。两根牵引缝线均缩短了后叶游离缘到PPM尖端的距离并减少了其移位,从而减少了二尖瓣反流。

结论

这种简单的修复技术可能是治疗缺血性二尖瓣反流时瓣环成形术的有用辅助方法。

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