Wozniak Milena, Murias Marek
Katedra i Zakład Toksykologii Uniwersytetu Medycznego w Poznaniu.
Ginekol Pol. 2008 Nov;79(11):785-90.
In recent years much attention has been paid to the issues of chemicals that disrupt the normal function of endocrine system, namely xenoestrogens. These chemicals can mimic the activity of endogenous estrogens, antagonize their interaction with estrogen receptors or disrupt the synthesis, metabolism and functions of endogenous female hormones. Due to the fact that they act thanks to many different mechanisms, it is very difficult to estimate their estrogenic activity by means of a simple tests. The important issue remains the fact that xenoestrogens may have a positive or negative influence on the function of the endocrine system. It seems to be very important that there are many sources of xenoestrogens, that is not only vegetables and fruit (phytoestrogens), but also metals (Co, Cu, Ni, Cr, Pb), dental appliances (alkilphenols), food containers or blood containers (PVC--polyvinyl chloride, DEHP--di-(2-ethylhexyl) phthalate), cosmetics (parabens) and pesticides (DDT--dichlor-diphenyl-trichlorethylane, endosulfane).
近年来，人们对扰乱内分泌系统正常功能的化学物质，即外源性雌激素，给予了极大关注。这些化学物质能够模拟内源性雌激素的活性，拮抗它们与雌激素受体的相互作用，或者干扰内源性女性激素的合成、代谢及功能。由于它们通过多种不同机制发挥作用，通过简单测试来评估其雌激素活性非常困难。一个重要问题是，外源性雌激素可能对内分泌系统功能产生正面或负面影响。外源性雌激素来源众多，这一点似乎非常重要，这些来源不仅包括蔬菜和水果（植物雌激素），还包括金属（钴、铜、镍、铬、铅）、牙科器械（烷基酚）、食品容器或血袋（聚氯乙烯、邻苯二甲酸二（2-乙基己基）酯）、化妆品（对羟基苯甲酸酯）以及杀虫剂（滴滴涕、硫丹）。
