Naftali Timna, Feingelernt Haya, Lesin Yevgeni, Rauchwarger Ariela, Konikoff Fred Meir
Department of Gastroenterology and Hepatology, Meir Medical Center, Kfar Saba, Israel.
Digestion. 2008;78(4):224-8. doi: 10.1159/000190975. Epub 2009 Jan 13.
To investigate the safety and efficacy of an extract of Ziziphus jujuba for chronic constipation.Constipated patients received liquid Z. jujuba or placebo for 12 weeks. Subjects completed questionnaires, a visual analog scale and transit time (TT) tests before and after treatment.
Of 37 patients with a prolonged TT, 18 received the study drug and 19 a placebo. Two (12%) of the study and 16 (84%) of the control group dropped out due to severe constipation. The TT decreased from 12.2 particles for the study group to 3 particles at week 11. Symptom severity ratings decreased from 6 and 6.2 to 2 and 5, and the quality of life score improved from 1.9 and 2.3 to 1.3 and 1.4 in the study and control groups, respectively.
Z. jujuba extract is an effective and safe treatment for chronic constipation.
研究酸枣提取物治疗慢性便秘的安全性和有效性。便秘患者接受酸枣液或安慰剂治疗12周。受试者在治疗前后完成问卷调查、视觉模拟量表和转运时间（TT）测试。
在37名转运时间延长的患者中，18人接受了研究药物，19人接受了安慰剂。研究组中有2人（12%）、对照组中有16人（84%）因严重便秘退出。研究组的转运时间从12.2个颗粒降至第11周时的3个颗粒。研究组和对照组的症状严重程度评分分别从6和6.2降至2和5，生活质量评分分别从1.9和2.3提高到1.3和1.4。
酸枣提取物是治疗慢性便秘的一种有效且安全的疗法。
