Notch 1使前体T细胞保持在正常发育路径上。

Notch 1 keeps pro-T cells on track.

作者信息

von Boehmer Harald

机构信息

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Immunity. 2009 Jan 16;30(1):5-7. doi: 10.1016/j.immuni.2008.12.008.

DOI:10.1016/j.immuni.2008.12.008

PMID:19144311

Abstract

In this issue of Immunity, Feyerabend et al. (2009) report that Delta-like 4, acting on Notch 1, prevents pro-T cells from differentiating into dendritic cells and B cells. In addition, in the absence of Notch 1, B cells in the thymus arose from a cell-extrinsic pathway.

摘要

在本期《免疫》杂志中，费耶拉本德等人（2009年）报告称，Delta样4作用于Notch 1，可阻止前T细胞分化为树突状细胞和B细胞。此外，在缺乏Notch 1的情况下，胸腺中的B细胞源自细胞外途径。