Uppuluri Sarada C, Storozynsky Eugene, Bisognano John D
Department of Internal Medicine, Cardiology Division, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Curr Hypertens Rep. 2009 Feb;11(1):69-75. doi: 10.1007/s11906-009-0013-x.
Despite therapy with multiple optimally dosed medications, hypertension remains poorly controlled in a sizeable number of people worldwide. This has spurred interest in exploring other pharmacologic and nonpharmacologic options for treatment. The carotid baroreceptors are important in regulating blood pressure in chronic hypertension by centrally mediated sympathoinhibitory effects and other effects. This has led to renewed interest in treating hypertension by electrically stimulating the carotid baroreceptors. Although this concept was first studied several decades ago, modern technology and better understanding of physiology have finally allowed the development of a feasible treatment option. Ongoing trials are finding significant and sustained reductions in blood pressure, a good safety profile, and tolerable side-effects. These promising results indicate that this modality has the potential to become a useful tool in future treatment of hypertension.
尽管使用了多种最佳剂量的药物进行治疗，但全球仍有相当一部分人的高血压控制不佳。这激发了人们探索其他药物和非药物治疗方案的兴趣。颈动脉压力感受器通过中枢介导的交感神经抑制作用和其他作用，在慢性高血压的血压调节中起着重要作用。这使得人们重新对通过电刺激颈动脉压力感受器来治疗高血压产生了兴趣。尽管这一概念早在几十年前就已被研究，但现代技术和对生理学的更深入理解最终促成了一种可行治疗方案的开发。正在进行的试验发现，血压有显著且持续的降低，安全性良好，副作用也可耐受。这些令人鼓舞的结果表明，这种治疗方式有可能成为未来治疗高血压的一种有用工具。
