持久突触可塑性和记忆的翻译调控
Translational control of long-lasting synaptic plasticity and memory.
作者信息
Costa-Mattioli Mauro, Sossin Wayne S, Klann Eric, Sonenberg Nahum
机构信息
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal QCH3G1Y6, Canada.
出版信息
Neuron. 2009 Jan 15;61(1):10-26. doi: 10.1016/j.neuron.2008.10.055.
Abstract
Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.
摘要
持久形式的突触可塑性和记忆依赖于新蛋白质的合成。从遗传学、生理学、药理学和生物化学研究中取得的最新进展提供了强有力的证据，表明翻译控制在调节神经回路的长期变化以及行为的长期改变中起着关键作用。翻译控制对于调节一般蛋白质合成以及响应神经元活动而合成特定蛋白质都很重要。在这篇综述中，我们总结并讨论了该领域的最新进展，并强调了更好地理解突触强度、学习和记忆的长期变化以及对神经疾病影响的前景。
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