Australian Technology Network Centre for Metabolic Fitness & Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
Fertil Steril. 2010 Mar 1;93(4):1173-8. doi: 10.1016/j.fertnstert.2008.12.003. Epub 2009 Jan 14.
To determine the effects of weight loss on heart rate recovery (HRR) in overweight women with polycystic ovary syndrome (PCOS).
A 10-week prospective clinical intervention.
Clinical research unit.
PATIENT(S): Fifty-seven overweight and obese women with PCOS (age: 29.8 +/- 0.8 years; body mass index [BMI] 36.2 +/- 0.7 kg/m(2)).
INTERVENTION(S): A dietary plan of 5-6 MJ/day ( approximately 30% energy restricted).
MAIN OUTCOME MEASURE(S): Heart rate recovery (defined as the reduction in heart rate after 1 minute from peak heart rate after a graded treadmill test to exhaustion), weight, waist circumference, blood pressure, glucose, insulin, homeostasis model assessment of insulin resistance, and sex steroids before and after the intervention.
RESULT(S): The mean percentage of weight loss was (-6.7 +/- 0.4%). There were significant reductions in waist circumference (-6.9 +/- 0.6 cm), blood pressure (-4.9/-2.5 +/- 1.2/1.2 mm Hg), fasting insulin (-3.4 +/- 0.7 mU/L), fasting glucose (-0.17 +/- 0.05 mmol/L), homeostasis model assessment of insulin resistance (-0.43 +/- 0.09), T (-0.38 +/- 0.07 nmol/L), free androgen index (-2.86 +/- 0.58), and an increase in sex hormone-binding globulin [SHBG] (5.86 +/- 1.12 nmol/L). The HRR improved from 30.9 +/- 1.1 to 38.0 +/- 1.1 beats/min and that was related to the reduction in body weight (r = -0.34) and waist circumference (r = -0.27).
CONCLUSION(S): Weight loss in overweight and obese women with PCOS is associated with improvements in HRR, which suggests improved autonomic function. This highlights the importance of weight loss to reduce the cardiovascular disease risk in these women.
确定减肥对超重多囊卵巢综合征（PCOS）女性心率恢复（HRR）的影响。
一项为期 10 周的前瞻性临床干预研究。
临床研究单位。
57 名超重和肥胖的多囊卵巢综合征女性（年龄：29.8±0.8 岁；体重指数 [BMI]36.2±0.7kg/m²）。
每天 5-6MJ 的饮食计划（约 30%能量限制）。
心率恢复（定义为从峰值心率后 1 分钟内心率的降低，峰值心率是在分级跑步机测试至衰竭后获得的）、体重、腰围、血压、血糖、胰岛素、胰岛素抵抗的稳态模型评估和性激素，干预前后。
体重减轻的平均百分比为（-6.7±0.4%）。腰围（-6.9±0.6cm）、血压（-4.9/-2.5±1.2/1.2mmHg）、空腹胰岛素（-3.4±0.7mU/L）、空腹血糖（-0.17±0.05mmol/L）、胰岛素抵抗的稳态模型评估（-0.43±0.09）、T（-0.38±0.07nmol/L）、游离雄激素指数（-2.86±0.58）和性激素结合球蛋白[SHBG]（5.86±1.12nmol/L）均显著降低。心率恢复从 30.9±1.1 增加到 38.0±1.1 次/分钟，与体重减轻（r=-0.34）和腰围减少（r=-0.27）相关。
超重和肥胖多囊卵巢综合征女性的体重减轻与 HRR 的改善有关，这表明自主神经功能得到改善。这突出了减肥对降低这些女性心血管疾病风险的重要性。
