Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China.
Fertil Steril. 2010 Mar 1;93(4):1260-6. doi: 10.1016/j.fertnstert.2008.11.024. Epub 2009 Jan 14.
To compared the plasma levels and the genetic polymorphism of myeloperoxidase in patients with pelvic inflammatory disease (PID) and healthy controls.
A random consecutive study.
University hospital.
PATIENT(S): Forty-four women who were diagnosed with PID.
INTERVENTION(S): Collected blood specimens of patients before and after they received treatment.
MAIN OUTCOME MEASURE(S): ELISA and polymerase chain reaction-restriction fragment length polymorphism were respectively used to measure the plasma levels and genetic polymorphism of myeloperoxidase.
RESULT(S): We found the plasma level of myeloperoxidase was elevated in PID patients compared with that in normal controls and decreased significantly compared with that in the same patients after they received treatment. PID patients with myeloperoxidase G/A alleles significantly tended to have elevated plasma concentration of myeloperoxidase, whereas PID patients with G/G homozygous alleles did not.
CONCLUSION(S): Elevated expression of myeloperoxidase may be involved in the pathogenesis of PID and could be useful for the diagnosis of PID. Furthermore, G/A alleles of myeloperoxidase may contribute to such elevation in PID patients.
比较盆腔炎（PID）患者与健康对照者的髓过氧化物酶（MPO）血浆水平和遗传多态性。
随机连续研究。
大学医院。
44 名被诊断为 PID 的女性。
在患者接受治疗前后采集血液标本。
酶联免疫吸附试验（ELISA）和聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分别用于测量 MPO 的血浆水平和遗传多态性。
与正常对照组相比，PID 患者的 MPO 血浆水平升高，治疗后明显降低。MPO G/A 等位基因的 PID 患者 MPO 血浆浓度明显升高，而 MPO G/G 纯合子等位基因的 PID 患者则没有。
MPO 的表达升高可能与 PID 的发病机制有关，对 PID 的诊断可能有用。此外，MPO 的 G/A 等位基因可能导致 PID 患者 MPO 水平升高。
