Delpisheh Ali, Brabin Loretta, Topping Joanne, Reyad Manal, Tang Ai-Wei, Brabin Bernard J
Child & Reproductive Health Group, Liverpool School of Tropical Medicine, UK.
Eur J Obstet Gynecol Reprod Biol. 2009 Mar;143(1):38-42. doi: 10.1016/j.ejogrb.2008.11.006. Epub 2009 Jan 14.
To determine the role of maternal CYP1A1, GSTT1, and GSTM1 metabolic gene polymorphisms in modulating the association between pregnancy smoking exposure and fetal growth restriction.
A case-control study was conducted to investigate if the association of pregnancy smoking and birth outcome was modulated by maternal gene polymorphisms. A total of 90 mothers with an IUGR baby (cases) and 180 mothers without IUGR (controls) were enrolled.
Almost half of smokers who carried a CYP1A1 variant (51.3%), GSTT1 null (43.6%), or GSTM1 null genotypes (64.1%) delivered a baby with IUGR. Smokers with the variant CYP1A1 "aa" genotype had babies with lower mean birthweight than non-smokers with the same genotype (p=0.004). An interaction test showed increased prevalence of IUGR in smokers with the CYP1A1 (Aa/aa) variant (adjusted OR, 1.9; 95% CI, 1.4-5.5, p=0.01), or with the GSTT1 null (AOR, 1.5; 1.1-3.1, p=0.001), or GSTM1 null genotypes (AOR, 1.5; 1.2-3.7, p=0.001).
Risk of fetal growth restriction in mothers who smoked during pregnancy was modulated by maternal metabolic gene polymorphisms. The genetic control of the conversion of toxic metabolites of tobacco smoke to less damaging substances is important for maternal and fetal health.
确定母亲CYP1A1、GSTT1和GSTM1代谢基因多态性在调节孕期吸烟暴露与胎儿生长受限之间关联中的作用。
进行了一项病例对照研究，以调查母亲基因多态性是否会调节孕期吸烟与出生结局之间的关联。共纳入90名有胎儿生长受限婴儿的母亲（病例组）和180名无胎儿生长受限的母亲（对照组）。
携带CYP1A1变异型（51.3%）、GSTT1缺失型（43.6%）或GSTM1缺失型基因型（64.1%）的吸烟者中，几乎一半分娩出胎儿生长受限的婴儿。携带CYP1A1变异型“aa”基因型的吸烟者所生婴儿的平均出生体重低于具有相同基因型的非吸烟者（p = 0.004）。交互作用检验显示，携带CYP1A1（Aa/aa）变异型（校正比值比，1.9；95%可信区间，1.4 - 5.5，p = 0.01）、GSTT1缺失型（校正比值比，1.5；1.1 - 3.1，p = 0.001）或GSTM1缺失型基因型的吸烟者中，胎儿生长受限的患病率增加（校正比值比，1.5；1.2 - 3.7，p = 0.001）。
孕期吸烟母亲发生胎儿生长受限的风险受母亲代谢基因多态性的调节。将烟草烟雾中的有毒代谢产物转化为危害较小物质的基因控制对母婴健康很重要。
