Fulda Simone
University Children's Hospital, Ulm, Germany.
Pediatr Blood Cancer. 2009 Oct;53(4):533-6. doi: 10.1002/pbc.21922.
Resistance to apoptosis (programmed cell death) is a characteristic feature of human cancers including childhood malignancies. Further, evasion of apoptosis is a frequent cause of treatment resistance, since most anti-cancer therapies, for example chemo- or radiotherapy act primarily by inducing apoptosis in cancer cells. Over the last two decades, the dissection of apoptosis pathways in pediatric tumors has resulted in the identification of many key molecules that may serve as molecular targets for drug discovery. Accordingly, components of the apoptotic cascade are currently exploited for the development of rationally designed molecular targeted therapies. This approach is expected to open new and more effective approaches for the treatment of childhood cancers.
对细胞凋亡（程序性细胞死亡）的抵抗是包括儿童恶性肿瘤在内的人类癌症的一个特征。此外，逃避细胞凋亡是治疗抵抗的常见原因，因为大多数抗癌疗法，如化疗或放疗，主要通过诱导癌细胞凋亡起作用。在过去二十年中，对儿科肿瘤细胞凋亡途径的剖析已导致鉴定出许多可能作为药物发现分子靶点的关键分子。因此，目前正在利用凋亡级联反应的组成部分来开发合理设计的分子靶向疗法。这种方法有望为儿童癌症的治疗开辟新的、更有效的途径。
