Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstr. 3a, 60528 Frankfurt/Main, Germany.
Cancer Lett. 2013 May 28;332(2):369-73. doi: 10.1016/j.canlet.2010.10.003. Epub 2010 Oct 30.
Evasion of apoptosis (programmed cell death) is a characteristic feature of human cancers including childhood malignancies. Since cytotoxic therapies such as chemotherapy or radiotherapy trigger apoptosis as a primary mechanism of action, resistance to apoptosis can also lead to treatment resistance. Studies on apoptosis pathways in childhood malignancies yielded a series of key molecules that can now be exploited as molecular targets for the development of targeted therapies. This strategy is anticipated to open novel perspectives for more effective treatment options for children with cancer.
细胞凋亡（程序性细胞死亡）的逃避是包括儿童恶性肿瘤在内的人类癌症的一个特征。由于细胞毒性疗法，如化疗或放疗，将细胞凋亡作为主要作用机制触发，因此对细胞凋亡的抵抗也可能导致治疗耐药。对儿童恶性肿瘤中的细胞凋亡途径的研究产生了一系列关键分子，这些分子现在可以作为靶向治疗开发的分子靶点加以利用。预计这种策略将为癌症患儿提供更有效治疗选择的新视角。
